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Healing & Recoverypreclinical

BPC-157

Body Protection Compound 157
Healing & Recovery · CAS 137525-51-0
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Category
Healing & Recovery
Evidence grade
D
PubMed records
211
Female-tagged
21
Sex-analysis
0
CAS
137525-51-0
D
Evidence grade D, Preclinical / animal evidence only across 211 indexed studies. No human trial data. How grades work →
Female evidence: None
BPC-157: of 211 PubMed records, 21 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-17. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

BPC-157 is a synthetic pentadecapeptide, a 15-amino-acid chain derived from a protein sequence found in gastric juice. It has become one of the most widely discussed compounds in the tissue-repair research conversation, and its stability and solubility have made it a common material in laboratory work on healing and cytoprotection.

In preclinical models, BPC-157 has been studied for its relationship to angiogenesis, growth-factor signaling, and the nitric-oxide system, most often in rodent tissue-injury protocols involving tendon, muscle, and gut. Researchers examining wound-healing mechanisms and gastrointestinal protection have returned to it repeatedly as a reference compound, which is part of why popular interest has run so far ahead of the clinical record.

That gap is the honest headline. Despite the volume of preclinical attention, controlled human trials have not been indexed, and the female-specific record is thinner still. For a catalog written around sex-disaggregated evidence, BPC-157 is a clear example of why the question of how many studies included women matters, because the mechanism data is real and the female data is essentially absent.

Summary

BPC-157 is a synthetic pentadecapeptide widely discussed for tissue healing. Despite heavy popular interest, the evidence base is almost entirely preclinical rodent studies, and no controlled human trials have been indexed, a gap that is even wider for female subjects.

Evidence in women

Menstrual cycle
Unstudied
No studies examine menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist. Absence of harm data is not evidence of safety.
Hormonal interactions
Unstudied
No data on estrogen, thyroid, or contraceptive interactions.
Perimenopause & menopause
Unstudied
No data in perimenopausal or menopausal populations.
Sex differences
Unstudied
In the indexed literature, small number using female animals reported no sex-stratified outcomes. Any dosing figure circulating online is extrapolated from male-animal data.

Mechanism

Proposed to promote angiogenesis and modulate the nitric-oxide system and growth-factor signaling; mechanisms characterized in rodent tissue-injury models.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Reported in animal studies only; no established human dose.
Routessubcutaneous, oral, intramuscular
Female-specific dosingNot established

Contraindications: active malignancy (theoretical, due to angiogenic activity)

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

insufficient human data to characterize

BPC-157 reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

1
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Draw for BPC-157

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from BPC-157's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is BPC-157?

BPC-157, also known as Body Protection Compound 157, is a research compound in our healing recovery category. BPC-157 is a synthetic pentadecapeptide widely discussed for tissue healing.

Is BPC-157 studied in women?

BPC-157: of 211 PubMed records, 21 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for BPC-157 is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has BPC-157 been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. Absence of harm data is not evidence of safety. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does BPC-157 have, and why?

BPC-157 carries evidence grade D. Preclinical / animal evidence only across 211 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for BPC-157?

No. A female-specific dose for BPC-157 is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is BPC-157 administered in research?

In the published literature, BPC-157 is administered via subcutaneous, oral, intramuscular. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for BPC-157?

Effects reported in the research literature include insufficient human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for BPC-157?

The CAS registry number for BPC-157 is 137525-51-0. It is also referred to as Body Protection Compound 157, Bepecin. Use it to confirm identity against a Certificate of Analysis.

How should BPC-157 be stored and handled?

BPC-157 sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy BPC-157 for research?

For laboratory research use, BPC-157 is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy BPC-157 at Aurevena Research
Research-use supplier: BPC-157 is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Buy now →

Further reading on BPC-157

The collagen cliff: why women's skin ages on a different clockArticle
Skin collagen falls by around 30% in the five years after menopause, and it tracks estrogen loss more closely than it tracks age. That single fact reframes almost every anti-aging peptide claim aimed at women.
9 min read
What is actually in GLOW and KLOWArticle
These blends are sold on the strength of their best-known ingredient. Here is the evidence for each of the three or four compounds inside, scored separately, including the route problem nobody mentions.
10 min read
Peptide reconstitution and storage: a laboratory handbookArticle
Lyophilized powder holds for years. The moment it goes into solution, a clock starts. Here is the arithmetic, the temperatures, and the handling errors that quietly cost potency.
13 min read
Peptide research combinations: what the literature actually studiesArticle
The 'stacking' conversation, translated into research terms, with the compliance and evidence caveats that come with it.
8 min read
Peptides 101: a women's guide to reading the researchArticle
What research peptides are, how the evidence is graded on this site, and why the sex-disaggregated question sits at the center of all of it.
8 min read
BPC-157 vs TB-500: comparing the recovery researchArticle
The two headline tissue-repair peptides, side by side, on mechanism, evidence stage, and the female-data question.
7 min read
Recovery and tendon-repair peptides: reading the researchArticle
The two most-discussed recovery peptides have deep preclinical files and shallow human, sex-stratified ones.
7 min read
Gut-research peptides: the evidence and its limitsArticle
BPC-157 and anti-inflammatory fragments dominate the gut-healing conversation, on almost entirely preclinical, male-weighted data.
7 min read
BPC-157 in women: a compound with no female dataArticle
A worked example of how to evaluate a popular peptide when the evidence base is entirely preclinical, and entirely male.
7 min read
How to read a Certificate of AnalysisArticle
A COA is the difference between a tested research compound and a claim on a label. Here is what each line actually tells you, what the headline purity figure quietly leaves out, and how to tie the document to the vial in your hand.
12 min read
Why almost every peptide study left women outArticle
For decades, research protected women by excluding them. The gap that policy created is the reason a database like this has to exist.
8 min read
Injectable vs. topical vs. oral: how route changes the evidenceGuide
The same compound can have solid evidence one way and almost none another. Route of administration is part of the evidence, not a footnote.
4 min read
The evidence-grade rubric, visualizedGuide
Every A–E grade on this site is computed from published fields, not assigned by opinion. This is the exact decision path.
4 min read
How a Certificate of Analysis is producedGuide
The five tests behind the paperwork, and the one thing that turns a test result into a Certificate of Analysis.
3 min read
Female vs. male evidence, compound by compoundGuide
A single chart of how thin the female evidence runs, even for the best-studied peptides in this database.
4 min read

Citations (PMID)

34064434 · 31500204

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.