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Performance & Muscleearly_human

Ipamorelin

NNC 26-0161
Performance & Muscle · CAS 170851-70-4
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Category
Performance & Muscle
Evidence grade
C
PubMed records
49
Female-tagged
14
Sex-analysis
0
CAS
170851-70-4
C
Evidence grade C, Early human data only (Phase 1 / small-n) across 49 indexed studies. How grades work →
Female evidence: None
Ipamorelin: of 49 PubMed records, 14 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-17. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Ipamorelin is a synthetic pentapeptide and a selective agonist of the ghrelin, or growth-hormone secretagogue, receptor (GHS-R). Its short five-residue structure and selectivity give it a clean, research-friendly profile that has made it a frequently studied tool compound in secretagogue work.

In preclinical and in-vitro models, ipamorelin has been studied for its stimulation of pulsatile growth-hormone-release pathways, and it is noted for engaging the GHS receptor with minimal effect on cortisol or prolactin signaling in the systems examined. Researchers characterizing secretagogue selectivity have used it as a research material because it isolates one pathway with relatively little cross-activity. Available human data is limited and dated, and sex-stratified reporting is largely absent.

What makes ipamorelin a useful entry for a performance and longevity catalog is precisely this selectivity, which lets investigators probe growth-hormone signaling with fewer confounding effects. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women. Supplied for in-vitro and laboratory research only.

Summary

Ipamorelin is a selective growth-hormone secretagogue studied in early human and animal work. Human data is limited and old; sex-stratified reporting is essentially absent, so claims about effects in women are extrapolated rather than measured.

Evidence in women

Menstrual cycle
Unstudied
No menstrual cycle interaction data.
Pregnancy & lactation
Unstudied
No pregnancy or lactation data.
Hormonal interactions
Unstudied
Growth-hormone axis interacts with estrogen, but no study characterizes this for ipamorelin in women.
Perimenopause & menopause
Unstudied
No data in perimenopausal or menopausal populations.
Sex differences
Unstudied
Few studies included female subjects, and none reported sex-stratified outcomes.

Mechanism

Selective agonist of the ghrelin/growth-hormone secretagogue receptor (GHS-R), stimulating pulsatile growth-hormone release with minimal effect on cortisol or prolactin.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Reported in early studies; no established therapeutic dose.
Routessubcutaneous
Female-specific dosingNot established

Contraindications: active malignancy (theoretical)

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

headacheinjection-site reactionstransient water retention

Ipamorelin reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

1
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Draw for Ipamorelin

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Ipamorelin's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Ipamorelin?

Ipamorelin, also known as NNC 26-0161, is a research compound in our performance muscle category. Ipamorelin is a selective growth-hormone secretagogue studied in early human and animal work.

Is Ipamorelin studied in women?

Ipamorelin: of 49 PubMed records, 14 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for Ipamorelin is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has Ipamorelin been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation data. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Ipamorelin have, and why?

Ipamorelin carries evidence grade C. Early human data only (Phase 1 / small-n) across 49 indexed studies.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Ipamorelin?

No. A female-specific dose for Ipamorelin is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Ipamorelin administered in research?

In the published literature, Ipamorelin is administered via subcutaneous. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Ipamorelin?

Effects reported in the research literature include headache, injection-site reactions, transient water retention. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for Ipamorelin?

The CAS registry number for Ipamorelin is 170851-70-4. It is also referred to as NNC 26-0161. Use it to confirm identity against a Certificate of Analysis.

How should Ipamorelin be stored and handled?

Ipamorelin sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Ipamorelin for research?

For laboratory research use, Ipamorelin is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy Ipamorelin at Aurevena Research
Research-use supplier: Ipamorelin is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Buy now →

Citations (PMID)

9849822

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AICARB
AICAR: of 2,496 PubMed records, 329 are tagged as including female subjects and 2 carry a sex-analysis tag.
CJC-1295 with DACC
CJC-1295 with DAC: of 32 PubMed records, 2 are tagged as including female subjects and 0 carry a sex-analysis tag.

Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.