For laboratory and educational research use only. Not medical advice.
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Skin & Hairpreclinical

Matrixyl

Palmitoyl Pentapeptide-4
Skin & Hair
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Category
Skin & Hair
Evidence grade
D
PubMed records
30
Female-tagged
5
Sex-analysis
0
CAS
—
D
Evidence grade D, Preclinical / animal evidence only across 30 indexed studies. No human trial data. How grades work →
Female evidence: None
Matrixyl: of 30 PubMed records, 5 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Matrixyl is a palmitoylated matrikine peptide built around a short signal fragment of type I collagen coupled to a palmitic-acid chain. The lipid modification improves its compatibility with skin-model systems, giving it a research-friendly profile as a tool compound in dermal-matrix studies.

In vitro and in preclinical skin models, Matrixyl has been studied for its relationship to extracellular-matrix signaling, including the stimulation of collagen and other matrix-component synthesis by dermal fibroblasts. Researchers examining matrikine biology have used it as a research material to probe how short peptide signals influence matrix turnover and repair pathways.

What makes Matrixyl a useful entry for a skin research catalog is its design as a defined matrikine mimic with a characterized signaling target. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

Matrixyl (palmitoyl pentapeptide-4) is a topical cosmetic peptide marketed to support collagen and reduce wrinkles. Its evidence base is small and largely formulation-driven; there are no rigorous sex-specific clinical analyses despite a predominantly female user base.

Evidence in women

Menstrual cycle
Unstudied
No study relates topical matrixyl to menstrual cycle phase.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data for cosmetic use.
Hormonal interactions
Unstudied
Skin collagen is estrogen-sensitive, but no matrixyl interaction data exist.
Perimenopause & menopause
Unstudied
Collagen falls sharply after menopause, but no menopause-specific matrixyl data exist.
Sex differences
Unstudied
Cosmetic studies did not analyze outcomes by sex.

Mechanism

A collagen-fragment-derived peptide proposed to signal fibroblasts to increase extracellular-matrix production when applied topically.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Used topically in cosmetic formulations; no systemic dose and limited clinical efficacy data.
Routestopical
Female-specific dosingNot established

Contraindications: insufficient data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

topical use; systemic effects not characterized

Matrixyl reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for Matrixyl

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Matrixyl's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Matrixyl?

Matrixyl, also known as Palmitoyl Pentapeptide-4, is a research compound in our skin hair category. Matrixyl (palmitoyl pentapeptide-4) is a topical cosmetic peptide marketed to support collagen and reduce wrinkles.

Is Matrixyl studied in women?

Matrixyl: of 30 PubMed records, 5 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for Matrixyl is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has Matrixyl been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data for cosmetic use. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Matrixyl have, and why?

Matrixyl carries evidence grade D. Preclinical / animal evidence only across 30 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Matrixyl?

No. A female-specific dose for Matrixyl is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Matrixyl administered in research?

In the published literature, Matrixyl is administered via topical. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Matrixyl?

Effects reported in the research literature include topical use; systemic effects not characterized. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should Matrixyl be stored and handled?

Matrixyl sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Matrixyl for research?

Matrixyl is not currently listed by our research-use partner, Aurevena Research, but their catalog carries related compounds. Code research15 applies 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Browse the Aurevena catalog
Research-use supplier: Matrixyl isn't currently listed by our research-use vendor. Their catalog carries related compounds. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Browse the catalog →

Citations (PMID)

22670614

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.