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Hormonal & Reproductiveapproved

Abaloparatide

BA058
Hormonal & Reproductive · CAS 247062-33-5
Category
Hormonal & Reproductive
Evidence grade
A
PubMed records
388
Female-tagged
168
Sex-analysis
2
CAS
247062-33-5
A
Evidence grade A, Approved indication with 168 indexed studies that included female subjects. How grades work →
Female evidence: Direct
Abaloparatide: of 388 PubMed records, 168 are tagged as including female subjects and 2 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-24. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Summary

Abaloparatide is a synthetic analog of parathyroid hormone-related protein (PTHrP) approved in 2017 for postmenopausal osteoporosis at high fracture risk. Its pivotal ACTIVE trial randomized 2,463 postmenopausal women and included a teriparatide comparator arm, so the two anabolic peptides have been compared head-to-head in women.

Evidence in women

Menstrual cycle
Unstudied
Trial population was postmenopausal; cycle phase was not a variable and has not been studied.
Pregnancy & lactation
Contraindicated
Not indicated in women of reproductive potential; no adequate human pregnancy or lactation data.
Hormonal interactions
Unstudied
Concurrent use with menopausal hormone therapy has not been a primary trial question.
Perimenopause & menopause
Evidence
The ACTIVE trial (Miller 2016) randomized 2,463 postmenopausal women to abaloparatide 80 mcg (n=824), placebo (n=821) or teriparatide (n=818) for 18 months, reporting an 86% relative reduction in new morphometric vertebral fractures for abaloparatide versus placebo. Postmenopausal osteoporosis is the approved indication.
Sex differences
No evidence
The primary evidence base is female because the approved indication is postmenopausal osteoporosis; comparative male data is far more limited, so a sex comparison cannot be drawn in the usual direction.

Mechanism

Selectively binds the RG conformation of the PTH type 1 receptor, producing a more transient signal than teriparatide. The shorter signal is the proposed reason for its bone-formation profile and lower rate of hypercalcemia.

Reported dosing & routes

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Approved labeling is 80 mcg subcutaneously once daily. This site does not publish personal dosing; the figure is the approved label value, given under prescription.
Routessubcutaneous
Female-specific dosingNot established

Contraindications: pregnancy and breastfeeding; pre-existing hypercalcemia; bone metastases or skeletal malignancy; prior radiation therapy to bone

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

hypercalciuriadizziness and orthostatic hypotensionnauseaheadachepalpitationsinjection-site reaction

Abaloparatide reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for Abaloparatide

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Abaloparatide's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Abaloparatide?

Abaloparatide, also known as BA058, is a research compound in our hormonal reproductive category. Abaloparatide is a synthetic analog of parathyroid hormone-related protein (PTHrP) approved in 2017 for postmenopausal osteoporosis at high fracture risk.

Is Abaloparatide studied in women?

Abaloparatide: of 388 PubMed records, 168 are tagged as including female subjects and 2 carry a sex-analysis tag. We grade this direct female evidence: at least one record carries a sex-analysis tag, so some findings are drawn from women rather than borrowed from mixed or male data. See how we read the evidence.

Has Abaloparatide been studied during pregnancy or breastfeeding?

Contraindicated. Not indicated in women of reproductive potential; no adequate human pregnancy or lactation data. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Abaloparatide have, and why?

Abaloparatide carries evidence grade A. Approved indication with 168 indexed studies that included female subjects.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Abaloparatide?

No. A female-specific dose for Abaloparatide is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Abaloparatide administered in research?

In the published literature, Abaloparatide is administered via subcutaneous. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Abaloparatide?

Effects reported in the research literature include hypercalciuria, dizziness and orthostatic hypotension, nausea, headache, palpitations, injection-site reaction. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for Abaloparatide?

The CAS registry number for Abaloparatide is 247062-33-5. It is also referred to as BA058, Tymlos, PTHrP(1-34) analog. Use it to confirm identity against a Certificate of Analysis.

How should Abaloparatide be stored and handled?

Abaloparatide sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Abaloparatide for research?

Abaloparatide is not currently listed by our research-use partner, Aurevena Research, but their catalog carries related compounds. Code research15 applies 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Browse the Aurevena catalog
Research-use supplier: Abaloparatide isn't currently listed by our research-use vendor. Their catalog carries related compounds. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Browse the catalog →

Citations (PMID)

27533157 · 11346808

Related peptides

Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.