For laboratory and educational research use only. Not medical advice.
Women's Peptide Research
Ask Vera
Home  /  Database  /  Gonadorelin
Hormonal & Reproductiveapproved

Gonadorelin

Factrel
Hormonal & Reproductive
ASK VERA ABOUT THIS ↗BROWSE THE CATALOG ↗
Category
Hormonal & Reproductive
Evidence grade
A
PubMed records
304
Female-tagged
173
Sex-analysis
0
CAS
—
A
Evidence grade A, Approved indication with 173 indexed studies that included female subjects. How grades work →
Female evidence: Direct
Gonadorelin: of 304 PubMed records, 173 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-17. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH), also known as LHRH, the hypothalamic decapeptide that sits at the top of the reproductive axis. Its identity to the native hormone gives it a well-defined pharmacology and makes it a natural reference material in neuroendocrine and reproductive research.

Gonadorelin acts as an agonist at pituitary GnRH receptors. Delivered in pulses, it has been studied for driving physiologic release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), while continuous stimulation instead downregulates the receptor, a contrast that has made it a useful probe of receptor dynamics. It has recognized clinical applications, including evaluation of pituitary gonadotropin function and, in pulsatile delivery, induction of ovulation in the setting of hypothalamic amenorrhea.

What makes gonadorelin notable for a hormonal and reproductive catalog is that it is one of the few compounds here with direct, established use in women, which means its underlying research base includes female physiology rather than treating it as an open question. Our evidence review tracks how that base is distributed across studies.

Summary

Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH, also called LHRH). It has approved clinical uses that are directly female: evaluating pituitary gonadotropin function, and, in pulsatile delivery, inducing ovulation in women with hypothalamic amenorrhea. It is one of the few compounds in this database with genuine, direct clinical use in women.

Evidence in women

Menstrual cycle
Evidence
Pulsatile gonadorelin has been used clinically to drive the menstrual cycle for ovulation induction, so its cycle effects are directly characterized in women.
Pregnancy & lactation
No evidence
Used before conception to induce ovulation, not administered during pregnancy; discontinue once pregnancy is achieved.
Hormonal interactions
Evidence
Directly upstream of the reproductive hormone axis (GnRH → LH/FSH); interactions with estrogen and progesterone feedback are well characterized.
Perimenopause & menopause
No evidence
Studied and used mainly in reproductive-age women; perimenopausal/menopausal-specific data is limited.
Sex differences
Evidence
Direct clinical use in women (ovulation induction and pituitary-axis diagnostics) gives it a genuinely female-relevant evidence base.

Mechanism

Agonist at pituitary GnRH receptors. Delivered in pulses, it drives physiologic LH and FSH release; continuous stimulation instead downregulates the receptor.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Diagnostic and pulsatile ovulation-induction regimens are described in the clinical literature (not advice).
Routesintravenous, subcutaneous
Female-specific dosingNot established

Contraindications: pregnancy; hormone-sensitive conditions (per clinical judgment)

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

headachenauseaflushinginjection-site reactions

Gonadorelin reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

1
2
3

Draw for Gonadorelin

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Gonadorelin's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Gonadorelin?

Gonadorelin, also known as Factrel, is a research compound in our hormonal reproductive category. Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH, also called LHRH).

Is Gonadorelin studied in women?

Gonadorelin: of 304 PubMed records, 173 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this direct female evidence: at least one record carries a sex-analysis tag, so some findings are drawn from women rather than borrowed from mixed or male data. See how we read the evidence.

Has Gonadorelin been studied during pregnancy or breastfeeding?

No evidence. Used before conception to induce ovulation, not administered during pregnancy; discontinue once pregnancy is achieved. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Gonadorelin have, and why?

Gonadorelin carries evidence grade A. Approved indication with 173 indexed studies that included female subjects.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Gonadorelin?

No. A female-specific dose for Gonadorelin is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Gonadorelin administered in research?

In the published literature, Gonadorelin is administered via intravenous, subcutaneous. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Gonadorelin?

Effects reported in the research literature include headache, nausea, flushing, injection-site reactions. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should Gonadorelin be stored and handled?

Gonadorelin sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Gonadorelin for research?

Gonadorelin is not currently listed by our research-use partner, Aurevena Research, but their catalog carries related compounds. Code research15 applies 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Browse the Aurevena catalog
Research-use supplier: Gonadorelin isn't currently listed by our research-use vendor. Their catalog carries related compounds. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Browse the catalog →

Related peptides

AbaloparatideA
Abaloparatide: of 388 PubMed records, 168 are tagged as including female subjects and 2 carry a sex-analysis tag.
Bremelanotide (PT-141)A
Bremelanotide (PT-141): of 111 PubMed records, 51 are tagged as including female subjects and 0 carry a sex-analysis tag.
Calcitonin (salmon)A
Calcitonin (salmon): of 1,852 PubMed records, 674 are tagged as including female subjects and 6 carry a sex-analysis tag.
Kisspeptin-10C
Kisspeptin-10: of 410 PubMed records, 182 are tagged as including female subjects and 1 carry a sex-analysis tag.

Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.