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Weight & Metabolicpreclinical

Adipotide

Prohibitin-TP01
Weight & Metabolic
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Category
Weight & Metabolic
Evidence grade
D
PubMed records
4
Female-tagged
2
Sex-analysis
0
CAS
—
D
Evidence grade D, Preclinical / animal evidence only across 4 indexed studies. No human trial data. How grades work →
Female evidence: None
Adipotide: of 4 PubMed records, 2 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Adipotide is a synthetic peptide construct designed to target prohibitin, a protein associated with the vasculature that supplies adipose tissue. Its targeting design gives it a research-friendly profile as a probe of the blood supply serving fat depots rather than of fat cells directly.

In preclinical models Adipotide has been studied for its relationship to prohibitin-associated adipose-tissue vasculature and the mechanisms by which the microvascular support of fat depots can be experimentally modulated. Researchers examining metabolic and adipose biology have used it as a research material to investigate these vascular-targeting pathways in cell-based and animal systems.

What makes Adipotide a notable entry for a metabolic research catalog is its focus on the vascular compartment of adipose tissue as a distinct experimental target. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

Adipotide is a peptidomimetic that targets the blood supply of white fat, causing weight loss in obese animals (including monkeys). It has not advanced to established human trials, earlier work flagged kidney effects, and there is no female-specific data.

Evidence in women

Menstrual cycle
Unstudied
No studies examine menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
No data on reproductive- or thyroid-hormone interactions.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data.
Sex differences
Unstudied
Preclinical studies did not report sex-stratified outcomes.

Mechanism

A targeting peptide linked to a pro-apoptotic sequence that homes to prohibitin on fat-tissue blood vessels, triggering their regression.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)No established human dose; weight loss shown in animal models, with dose-limiting kidney effects noted.
Routessubcutaneous
Female-specific dosingNot established

Contraindications: kidney impairment (renal effects reported in animals)

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

kidney effects (preclinical)insufficient human data to characterize

Adipotide reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for Adipotide

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Adipotide's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Adipotide?

Adipotide, also known as Prohibitin-TP01, is a research compound in our weight metabolic category. Adipotide is a peptidomimetic that targets the blood supply of white fat, causing weight loss in obese animals (including monkeys).

Is Adipotide studied in women?

Adipotide: of 4 PubMed records, 2 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for Adipotide is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has Adipotide been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Adipotide have, and why?

Adipotide carries evidence grade D. Preclinical / animal evidence only across 4 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Adipotide?

No. A female-specific dose for Adipotide is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Adipotide administered in research?

In the published literature, Adipotide is administered via subcutaneous. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Adipotide?

Effects reported in the research literature include kidney effects (preclinical), insufficient human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should Adipotide be stored and handled?

Adipotide sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Adipotide for research?

Adipotide is not currently listed by our research-use partner, Aurevena Research, but their catalog carries related compounds. Code research15 applies 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Browse the Aurevena catalog
Research-use supplier: Adipotide isn't currently listed by our research-use vendor. Their catalog carries related compounds. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Browse the catalog →

Citations (PMID)

22072637 · 40591817

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.