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AOD-9604

hGH Fragment 176-191 (modified)
Weight & Metabolic · CAS 221231-10-3
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Category
Weight & Metabolic
Evidence grade
C
PubMed records
22
Female-tagged
3
Sex-analysis
0
CAS
221231-10-3
C
Evidence grade C, Early human data only (Phase 1 / small-n) across 22 indexed studies. How grades work →
Female evidence: Extrapolated
AOD-9604: of 22 PubMed records, 3 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

AOD-9604 is a synthetic peptide based on the C-terminal fragment (residues 176 to 191) of human growth hormone, modified with an N-terminal tyrosine to improve stability. Because it corresponds only to this short fragment, it has a research-friendly profile as a tool for studying activity attributed to that region independently of the full hormone.

In laboratory models AOD-9604 has been studied for its relationship to lipid-metabolism enzyme signaling and has been characterized as acting independently of the growth-hormone receptor in vitro and in preclinical systems. Researchers examining fat-metabolism pathways have used it as a research material to investigate how this fragment behaves in cell-based assays.

What makes AOD-9604 a notable entry for a metabolic research catalog is its origin as a defined growth-hormone fragment paired with a distinct, receptor-independent studied mechanism. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

AOD-9604 is a modified fragment of human growth hormone (176–191) originally developed as an anti-obesity agent. It reached Phase 2b human trials that did not show significant weight loss over placebo, and no female-specific efficacy or safety analyses have been published.

Evidence in women

Menstrual cycle
Unstudied
No study examined menstrual cycle effects.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
No data on interactions with reproductive or thyroid hormones.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data.
Sex differences
Unstudied
Obesity trials included women, but outcomes were not reported by sex, and the trials did not demonstrate efficacy for either sex.

Mechanism

An hGH(176-191) fragment proposed to stimulate lipolysis and inhibit lipogenesis without the growth-promoting effects of full-length growth hormone.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Up to ~1 mg/day oral studied in Phase 2 obesity trials; no efficacious dose established.
Routesoral, subcutaneous
Female-specific dosingNot established

Contraindications: insufficient data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

generally well tolerated in trials; no significant weight-loss benefit over placebo demonstrated

AOD-9604 reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for AOD-9604

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from AOD-9604's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is AOD-9604?

AOD-9604, also known as hGH Fragment 176-191 (modified), is a research compound in our weight metabolic category. AOD-9604 is a modified fragment of human growth hormone (176–191) originally developed as an anti-obesity agent.

Is AOD-9604 studied in women?

AOD-9604: of 22 PubMed records, 3 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this extrapolated: women appear in the record, but no study is tagged for a sex-specific analysis, so female-relevant conclusions are inferred from mixed or male data rather than measured in women. See our methodology.

Has AOD-9604 been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does AOD-9604 have, and why?

AOD-9604 carries evidence grade C. Early human data only (Phase 1 / small-n) across 22 indexed studies.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for AOD-9604?

No. A female-specific dose for AOD-9604 is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is AOD-9604 administered in research?

In the published literature, AOD-9604 is administered via oral, subcutaneous. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for AOD-9604?

Effects reported in the research literature include generally well tolerated in trials; no significant weight-loss benefit over placebo demonstrated. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for AOD-9604?

The CAS registry number for AOD-9604 is 221231-10-3. It is also referred to as hGH Fragment 176-191 (modified), AOD9604. Use it to confirm identity against a Certificate of Analysis.

How should AOD-9604 be stored and handled?

AOD-9604 sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy AOD-9604 for research?

For laboratory research use, AOD-9604 is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy AOD-9604 at Aurevena Research
Research-use supplier: AOD-9604 is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Buy now →

Citations (PMID)

15134286 · 16931496 · 41966639

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.