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Immunepreclinical

KPV

Lysine-Proline-Valine
Immune · CAS 67727-97-3
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Category
Immune
Evidence grade
D
PubMed records
47
Female-tagged
2
Sex-analysis
0
CAS
67727-97-3
D
Evidence grade D, Preclinical / animal evidence only across 47 indexed studies. No human trial data. How grades work →
Female evidence: None
KPV: of 47 PubMed records, 2 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

KPV is a tripeptide composed of lysine, proline, and valine, corresponding to the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). Its small, three-residue structure gives it a research-friendly profile, and it is often studied as a way to isolate the anti-inflammatory portion of the larger melanocortin peptide without its pigmentary activity.

In preclinical and in-vitro systems, KPV has been studied for its relationship to inflammatory-response signaling, including modulation of NF-kappaB activity and pro-inflammatory cytokine pathways. Researchers examining gut-epithelial, dermal, and immune-cell models have used it as a research material to probe melanocortin-related mechanisms of inflammation regulation.

What makes KPV a useful entry for an immune-signaling catalog is the way its minimal structure narrows the studied mechanism to a defined fragment. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-MSH, investigated for anti-inflammatory activity in gut and skin models. The evidence base is entirely preclinical, rodent and cell studies, so no human trials and, consequently, no female-specific data have been indexed.

Evidence in women

Menstrual cycle
Unstudied
No studies examine menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist; absence of harm data is not evidence of safety.
Hormonal interactions
Unstudied
No data on estrogen, thyroid, or contraceptive interactions.
Perimenopause & menopause
Unstudied
No data in perimenopausal or menopausal populations.
Sex differences
Unstudied
Preclinical studies did not report sex-stratified outcomes; there is no human sex-difference data.

Mechanism

Retains part of the anti-inflammatory activity of alpha-MSH, acting on melanocortin pathways and NF-κB signaling to dampen inflammatory responses in preclinical models.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)No established human dose; anti-inflammatory activity characterized in preclinical models only.
Routesoral, subcutaneous
Female-specific dosingNot established

Contraindications: insufficient human data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

insufficient human data to characterize

KPV reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

1
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Draw for KPV

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from KPV's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is KPV?

KPV, also known as Lysine-Proline-Valine, is a research compound in our immune category. KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-MSH, investigated for anti-inflammatory activity in gut and skin models.

Is KPV studied in women?

KPV: of 47 PubMed records, 2 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for KPV is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has KPV been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist; absence of harm data is not evidence of safety. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does KPV have, and why?

KPV carries evidence grade D. Preclinical / animal evidence only across 47 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for KPV?

No. A female-specific dose for KPV is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is KPV administered in research?

In the published literature, KPV is administered via oral, subcutaneous. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for KPV?

Effects reported in the research literature include insufficient human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for KPV?

The CAS registry number for KPV is 67727-97-3. It is also referred to as Lysine-Proline-Valine, Lys-Pro-Val, α-MSH (11-13). Use it to confirm identity against a Certificate of Analysis.

How should KPV be stored and handled?

KPV sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy KPV for research?

For laboratory research use, KPV is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy KPV at Aurevena Research
Research-use supplier: KPV is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
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Citations (PMID)

11268347 · 12851308 · 11268348

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.