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Immunepreclinical

Thymogen

Glutamyl-Tryptophan
Immune
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Category
Immune
Evidence grade
D
PubMed records
89
Female-tagged
26
Sex-analysis
0
CAS
—
D
Evidence grade D, Preclinical / animal evidence only across 89 indexed studies. No human trial data. How grades work →
Female evidence: None
Thymogen: of 89 PubMed records, 26 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Thymogen is a synthetic dipeptide developed as an immunomodulatory tool compound. Its very short, two-residue structure gives it a simple and stable profile that is convenient for laboratory handling, and it belongs to the broader family of thymic-derived and thymic-inspired peptides studied in immunology.

In preclinical research, thymogen has been studied for its modeled role in immune-regulation, including effects on lymphocyte populations and on the signaling pathways that govern immune balance. Investigators examining immunomodulatory mechanisms have used it as a research material to probe how minimal peptide structures relate to regulatory immune responses in vitro and in animal models.

What makes thymogen notable for an immunology catalog is the contrast between its minimal structure and its studied regulatory activity. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

Thymogen is a synthetic dipeptide (glutamyl-tryptophan) developed in Russia as an immunomodulator. Its human evidence comes largely from the Russian clinical literature with limited independent replication, and no female-specific outcomes are isolated.

Evidence in women

Menstrual cycle
Unstudied
No study examines menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
No controlled data on reproductive- or thyroid-hormone interactions.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data.
Sex differences
Unstudied
Reports included women but were not analyzed by sex and lack independent replication.

Mechanism

A synthetic dipeptide proposed to normalize T-cell-mediated immune responses; also studied as an interferon inducer.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Intranasal and intramuscular regimens are described in the Russian literature; no independently standardized dose.
Routesintranasal, intramuscular
Female-specific dosingNot established

Contraindications: insufficient independently-verified data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

insufficient rigorous human data to characterize

Thymogen reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for Thymogen

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Thymogen's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Thymogen?

Thymogen, also known as Glutamyl-Tryptophan, is a research compound in our immune category. Thymogen is a synthetic dipeptide (glutamyl-tryptophan) developed in Russia as an immunomodulator.

Is Thymogen studied in women?

Thymogen: of 89 PubMed records, 26 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for Thymogen is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has Thymogen been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Thymogen have, and why?

Thymogen carries evidence grade D. Preclinical / animal evidence only across 89 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Thymogen?

No. A female-specific dose for Thymogen is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Thymogen administered in research?

In the published literature, Thymogen is administered via intranasal, intramuscular. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Thymogen?

Effects reported in the research literature include insufficient rigorous human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should Thymogen be stored and handled?

Thymogen sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Thymogen for research?

Thymogen is not currently listed by our research-use partner, Aurevena Research, but their catalog carries related compounds. Code research15 applies 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Browse the Aurevena catalog
Research-use supplier: Thymogen isn't currently listed by our research-use vendor. Their catalog carries related compounds. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Browse the catalog →

Citations (PMID)

38732260 · 19355963

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LL-37D
LL-37: of 2,527 PubMed records, 501 are tagged as including female subjects and 2 carry a sex-analysis tag.
ThymalinD
Thymalin: of 234 PubMed records, 75 are tagged as including female subjects and 0 carry a sex-analysis tag.

Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.