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Hormonal & Reproductiveapproved

Teriparatide

PTH(1-34)
Hormonal & Reproductive · CAS 52232-67-4
Category
Hormonal & Reproductive
Evidence grade
A
PubMed records
4,368
Female-tagged
1,826
Sex-analysis
30
CAS
52232-67-4
A
Evidence grade A, Approved indication with 1826 indexed studies that included female subjects. How grades work →
Female evidence: Direct
Teriparatide: of 4,368 PubMed records, 1,826 are tagged as including female subjects and 30 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-24. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Summary

Teriparatide is the first 34 amino acids of human parathyroid hormone and the first bone-anabolic drug approved for osteoporosis. Its pivotal fracture trial enrolled 1,637 postmenopausal women, making it one of the very few peptides whose primary evidence base is female by design rather than by accident.

Evidence in women

Menstrual cycle
Unstudied
The trial population was postmenopausal, so menstrual-cycle interactions were not a study variable and remain unexamined.
Pregnancy & lactation
Contraindicated
Contraindicated in pregnancy and breastfeeding. There is no adequate human data and the label excludes use.
Hormonal interactions
Evidence
Studied alongside and sequentially with estrogen therapy and antiresorptives; the interaction with prior bisphosphonate use in particular has been examined in trials that were female-majority.
Perimenopause & menopause
Evidence
The pivotal fracture trial (Neer 2001) randomized 1,637 postmenopausal women with prior vertebral fracture and reported a reduced risk of new vertebral fracture (RR 0.35) and non-vertebral fragility fracture (RR 0.47) versus placebo. Postmenopausal osteoporosis is the primary approved indication.
Sex differences
Evidence
Approved for men as well as postmenopausal women, so both populations have trial data; the female evidence base is substantially the larger of the two, which is the reverse of the usual pattern in this database.

Mechanism

Intermittent once-daily exposure to PTH(1-34) stimulates osteoblast activity more than osteoclast activity, shifting bone remodeling toward formation. The intermittent pattern is essential: continuous PTH elevation, as in hyperparathyroidism, drives bone loss instead.

Reported dosing & routes

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Approved labeling is 20 mcg subcutaneously once daily. This site does not publish personal dosing; the figure is the approved label value, given under prescription.
Routessubcutaneous
Female-specific dosingNot established

Contraindications: pregnancy and breastfeeding; prior external-beam or implant radiation to bone; pre-existing hypercalcemia; unexplained elevated alkaline phosphatase / Paget disease; bone metastases or skeletal malignancy

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

nausealeg crampsdizziness and orthostatic hypotension after early dosestransient hypercalcemiainjection-site reaction

Teriparatide reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for Teriparatide

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Teriparatide's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Teriparatide?

Teriparatide, also known as PTH(1-34), is a research compound in our hormonal reproductive category. Teriparatide is the first 34 amino acids of human parathyroid hormone and the first bone-anabolic drug approved for osteoporosis.

Is Teriparatide studied in women?

Teriparatide: of 4,368 PubMed records, 1,826 are tagged as including female subjects and 30 carry a sex-analysis tag. We grade this direct female evidence: at least one record carries a sex-analysis tag, so some findings are drawn from women rather than borrowed from mixed or male data. See how we read the evidence.

Has Teriparatide been studied during pregnancy or breastfeeding?

Contraindicated. Contraindicated in pregnancy and breastfeeding. There is no adequate human data and the label excludes use. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Teriparatide have, and why?

Teriparatide carries evidence grade A. Approved indication with 1826 indexed studies that included female subjects.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Teriparatide?

No. A female-specific dose for Teriparatide is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Teriparatide administered in research?

In the published literature, Teriparatide is administered via subcutaneous. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Teriparatide?

Effects reported in the research literature include nausea, leg cramps, dizziness and orthostatic hypotension after early doses, transient hypercalcemia, injection-site reaction. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for Teriparatide?

The CAS registry number for Teriparatide is 52232-67-4. It is also referred to as PTH(1-34), Forteo, recombinant human parathyroid hormone (1-34). Use it to confirm identity against a Certificate of Analysis.

How should Teriparatide be stored and handled?

Teriparatide sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Teriparatide for research?

Teriparatide is not currently listed by our research-use partner, Aurevena Research, but their catalog carries related compounds. Code research15 applies 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Browse the Aurevena catalog
Research-use supplier: Teriparatide isn't currently listed by our research-use vendor. Their catalog carries related compounds. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Browse the catalog →

Citations (PMID)

11346808 · 27533157

Related peptides

Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.